Chronic pain, anxiety, insomnia, irritable-bowel flares—these are the top four reasons adults seek medical cannabis cards. Each is modulated not only by peripheral nociceptive signals but also by attention, catastrophizing, and the appraisal circuits of the medial prefrontal cortex.1 At the same time, mindfulness-based stress reduction (MBSR), breath-work, and focused-attention meditation reliably down-shift amygdala activity and increase parasympathetic tone…